My research program focuses on three independent but related fields of research that have both basic (curiosity driven) and applied (health sciences) aspects to them: 1) Stroke Recovery, 2) Epilepsy & Seizure Disorders, and 3) The Cellular/Synaptic Basis of Learning & Memory. My work uses animal models of diseases, syndromes and treatments. I measure animal behaviour using a variety of assessment techniques (e.g. open field, single pellet reaching task, pasta matrix task, elevated plus maze, cylinder task, ladder task). I also use behavioural experience (skilled-reaching, wheel running, enriched environments) to understand how the brain changes. I employ electrophysiological (Intracortical microstimulation, EEG, evoked potentials, multi- and single-unit activity), and pharmacological (systemic and focal infusions) techniques to elucidate the underlying mechanisms. In collaboration with a number of colleagues I have also examined alterations in neural and glial cell anatomy at the cellular, ultrastructural and molecular/genetic levels.
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Natural Sciences and Engineering Research Council of Canada
Canadian Stroke Network: Networks of Centres for Excellence
Canadian Institute of Health Research
National Institute of Health
Learning and Memory mechanisms
Kindling and Long-term Potentiation
Seizures, Epilepsy, Stereotypic and Neurodegenerative Disorders