UofC Navigation
Site Navigation

Michael Antle

photograph of Michael Antle

Job Title:

  • Associate Professor

Phone:

  • +1 (403) 220-2574

Office:

  • A 18

Degrees:

  • 1994 - B.Sc. (Honours) - Psychology - Dalhousie University
  • 1998 - M.A. Psychology - Simon Fraser University
  • 2001 - Ph.D. Psychology - Simon Fraser University

Research Interests:

  • In our lab, we study the mammalian circadian system. This experimental model is ideal for understanding the regulations of behavior at many different levels of analysis. The circadian clock controls easily measurable behavioral and physiological processes. We know that the circadian clock is located in the brain in the suprachiasmatic nucleus (SCN). We know that some individual cells within the SCN contain a molecular clock that results from a transcription / translation feedback loop. By studying this elegant system, we can begin to understand how complex behaviors are regulated at the level of the brain, the cell, the genome and the molecule.

    Currently, the main focus of research in the lab is geared towards understanding how the various cell-type in the circadian clock are organized. Each cell population appears to serve a specific function. We would like to undertand how these groups are wired together. Furthermore, we would like to understand the behavioral and molecular effects of the specific neurotransmitters found in these seperate cell populations.

Research Support:

  • University of Calgary Startup Grant
    University of Calgary URGC Starter Grant
    NSERC Discovery Grant
    NSERC RTI Grant
    Canadian Hunter Explorations Young Innovator Award
    Canadian Foundation For Innovation
    Alberta Science and Research Authority

Masters:

  • Glenn Yamakawa (2009)
  • Roxanne Sterniczuk (2008)

Past Courses:

  • PSYC375 - Brain And Behaviour
  • PSYC476 - Physiological Psychology
  • PSYC476A - Physiological Psychology
  • PSYC476B - Physiological Psychology
  • PSYC504.75 - Research In Circadian Rhythms
  • PSYC504.75A - Research In Circadian Rhythms
  • PSYC504.84 - Res In Behavioural Neuroscience
  • PSYC504.84A - Res In Behavioural Neuroscience
  • PSYC505 - Research in Psychology
  • PSYC507.89 - Selected Topics in Psychology
  • PSYC507 - Selected Topics in Psychology
  • PSYC603.36 - Grad Conference Course in Psyc
  • PSYC603.37 - Grad Conference Course in Psyc
  • PSYC631.8 - Adv Top Behaviour Neuroscience
  • PSYC631.10 - Adv Top Behaviour Neuroscience
  • PSYC731.1 - Sem Behavioural Neuroscience
Representative Publications:
Journal Articles - Peer Reviewed
Sterniczuk, R., Colijn, Mark., Nunez, Maria. & Antle, M. (2010) Investigating the role of substance P in photic responses of the circadian system: Individual and combined actions with gastrin-releasing peptide. Neuropharmacology: Special Issue on Neuropeptides, 58(1), 277-85
Antle, M., Smith, V., Sterniczuk, R., Yamakawa, G. & Rakai, B. (2009) Physiological responses of the circadian clock to acute light exposure at night. Reviews in Endocrine and Metabolic Disorders: Special Issue on Circadian Rhythms (to appear)
Phillips, Catie., Smith, V., Antle, M. & Dyck, R. (2009) Neonatal medial frontal cortex lesions disrupt circadian activity patterns Developmental Neuroscience (to appear)
Sterniczuk, R., Stepkowski, Alexandra., Jones, Marie. & Antle, M. (2008) Enhancement of photic shifts with 5-HT1A mixed agonist/antagonist NAN-190: Intra suprachiasmatic nucleus pathway. Neuroscience, 153(3), 571-80
Antle, M., Tse, Floria., Koke, Sydney., Sterniczuk, R. & Hagel, Kimberly. (2008) Non-photic phase shifting of the circadian clock: Role of ERK/MAPK pathway. European Journal of Neuroscience, 28, 2511-8
Smith, V., Sterniczuk, R., Phillips, C. & Antle, M. (2008) Altered responses to photic and non-photic treatments in 5-HT1A knockout mice. Neuroscience, 157(3), 513-23
Antle, M., Sterniczuk, R., Smith, VM. & Hagel, K. (2007) Long light pulses reset the circadian clock through photic and nonphotic mechanisms. Journal of Biological Rhythms
Indic, P., Schwartz, WJ., Herzog, ED., Foley, NC. & Antle, M. (2007) Modeling the behavior of coupled cellular circadian oscillators in the suprachiasmatic nucleus. Journal of Biological Rhythms (to appear)
Antle, M., Sterniczuk, R., Smith, V. & Hagel, Kimberly. (2007) Non-photic modulation of phase shifts to long light pulses. Journal of Biological Rhythms, 22(6), 524-33
Antle, M., Foley, NC., Foley, DK. & Silver, R. (2007) Gates and oscillators II: Zeitgebers and the network model of the brain clock. Journal of Biological Rhythms, 22(1), 14-25
Mistleberger, RE. & Antle, M. (2006) The enigma of behavioral inputs to the circadian clock: a test of function using restraint. Physiology and Behavior, 87(5), 948-954
Antle, M., LeSauter, R. & Silver, R. (2005) Neurogenesis and ontogeny of specific cell phenotypes within the hamster suprachiasmatic nucleus. Developmental Brain Research, 157(1), 8-18
Antle, M., Kriegsfeld, LJ. & Silver, R. (2005) Signaling within the brain’s master clock: Localized activation of MAP kinase by gastrin-releasing peptide. Journal of Neuroscience, 25, 2447-2454
Antle, M. & Silver, R. (2005) Orchestrating Time: Arrangements of the Brain Circadian Clock. Trends in Neuroscience, 28(3), 145-151
Hamada, T., Antle, M. & Silver, R. (2004) The role of Period1 in non-photic resetting of the hamster circadian pacemaker in the suprachiasmatic nucleus. Neuroscience Letters, 362(2), 87-90
Hamada, T., Antle, M. & Silver, R. (2004) Temporal/spatial expression patterns of canonical clock genes and clock-controlled genes in the suprachiasmatic nucleus. European Journal of Neuroscience, 19(7), 1741-1748
Mistleberger, RE., Antle, M., Webb, IC., Jones, M., Weinberg, J. & Pollock, MS. (2003) Circadian clock resetting by arousal in Syrian hamsters: The role of stress and activity. American Journal of Physiology, 285, R917-R925
Antle, M., Foley, DK., Foley, NC. & Silver, R. (2003) Gates and oscillators: A network model of the brain clock. Journal of Biological Rhythms, 18, 339-350
Antle, M., Ogilvie, MD., Pickard, GE. & Mistleberger, RE. (2003) Response of the mouse circadian system to serotonin 1A/2/7 agonists in vivo: Surprisingly little. Journal of Biological Rhythms, 18, 145-158
Mistleberger, RE., Antle, M., Kilduff, T. & Jones, M. (2003) Food- and light-entrained circadian rhythms in rats with hypocretin-2-saporin ablations of the lateral hypothalamus. Brain Research, 980(2), 161-168
Mistleberger, RE., Belcourt, J. & Antle, M. (2002) Circadian clock resetting by sleep deprivation without exercise in Syrian hamsters: dark pulses revisited. Journal of Biological Rhythms, 17, 227-237
Antle, M., Ludgate, SA. & Mistleberger, RE. (2002) Activity-induced circadian clock resetting in the Syrian hamster: Effects of melatonin. Neuroscience Letters, 317, 5-8
Invited Lectures/Presentations
Antle, M. (2007) Resetting the Circadian Clock
Antle, M. (2005) Gates and oscillators: A network model of the mammalian circadian clock.
Antle, M. (2004) Circadian Timekeeping: Behavioral and Molecular Correlates.
Antle, M. (2003) Networks within the mammalian circadian clock: Organization and division of labor.
Antle, M. (2003) Circadian clock resetting by arousal in Syrian hamsters: The role of stress and activity.
Book Chapters/Contributions - Peer Reviewed
Antle, M. (2007) The circadian clock: Physiology, genes and disease. In The Visual Transduction Cascade: Basic and Clinical Principles. Series: Ophthalmology Research., Humana Press Inc.
Antle, M. & Mistleberger, RE. (2005) Circadian rhythms. In The Behaviour of the Laboratory Rat: A Handbook With Tests. (183-194), Oxford University Press Canada
Conference Papers / Abstracts
Stepkowski, Alexandra., Jones, Marie. & Antle, M. (2007) Resolving the photic pathway: Serotonergic modulation of gene expression.
Smith, Victoria M. & Antle, M. (2007) Blinded by the light, revved up like a mouse, another runner in the night.
Hagel, Kimberly. & Antle, M. (2007) Enhancement of photic phase shifts: Localization of c-fos expression in the circadian clock.
Young, Calvin. & Antle, M. (2007) Vasopressin-induced flank marking in different social contexts.
Sterniczuk, R. & Antle, M. (2007) NAN-190 and enhancement of photic phase shifts: Resolving the intra-SCN pathways.
Smith, V. & Antle, M. (2006) The role of the 5-HT1A receptor in serotonergic enhancement of photic phase shifts.
Tse, F. & Antle, M. (2006) Sleep deprivation down regulates ERK I/II phosphorylation within the suprachiasmatic nucleus.
Antle, M., Foley, N.C. & Silver, R. (2006) Gates and oscillators: A network model of the mammalian circadian clock.
Smith, V. & Antle, M. (2006) Serotonergic modulation of photic phase shifts: The role of the 5HT1A receptor.
Tse, F. & Antle, M. (2006) Non-photic down regulation of ERK1/2 phosphorylation within the SCN of the Syrian hamster.
Sterniczuk, R., Dyck, R. & Antle, M. (2006) Mice who forgot they can't dance: Circadian rhythmicity in a mouse model of Alzheimer's.
Sterniczuk, R., Rakai, B. & Antle, M. (2006) Enhancement of photic shifts with 5HT1A partial antagonist NAN-190: Intra SCN pathways.
Antle, M. (2005) Signaling within the circadian clock.
Antle, M., Foley, N.C. & Silver, R. (2005) Gates and oscillators: Zeitgebers and the network model of the brain clock.
Antle, M. & Silver, R. (2004) Intra-SCN Signaling: Gastrin-Releasing Peptide Activates “Cap” Cells of the SCN
Antle, M. & Silver, R. (2003) Neurogenesis of specific cell phenotypes within the hamster suprachiasmatic nucleus.
Webb, I., Antle, M., Jones, M., Weinberg, J., Pollock, M. S. & Mistlberger, R. (2003) Circadian clock resetting by arousal in Syrian hamsters: The role of stress and activity.
Antle, M., Hamada, T. & Silver, R. (2002) Non-photic phase shifts require the activity of voltage-gated Na+ channels within the SCN.
Antle, M., Foley, D.K. & Silver, R. (2002) Gates and oscillators: how to build a brain clock out of independent oscillators.

  • GradPhotos poster.jpg
    Graduating this year? Schedule your Grad Photos in Admin 170.